个人信息

姓名：郭瑞

学历：博士

职称：研究员

E-mail：ruiguo@ccnu.edu.cn

课题组网站：https://www.x-mol.com/groups/Zhang_Guozhu

教育与研究经历

2023年3月-至今，华中师范大学，化学学院，研究员

2020年12月-2023年3月，中国科学院上海有机化学研究所，助理研究员

2018年9月-2020年9月，美国匹兹堡大学，化学系，博士后，合作导师：Prof. Yiming Wang

2015年9月-2018年6月，中国科学院上海有机化学研究所，博士，导师：张国柱研究员

2012年9月-2015年6月，兰州大学，化学化工学院， 硕士，导师：翟宏斌教授

2008年9月-2012年6月，中国海洋大学，医药学院，学士

研究领域与兴趣

1.过渡金属催化有机合成方法学

2.自由基介导的碳氢键官能团化反应

3.有机氟化学

4.生物活性分子的合成与功能优化

招生方向

1.有机化学

承担项目与课题信息

1.国家自然科学基金青年项目，2024.01-2026.12，主持

2.华中师范大学高层次人才启动经费，2023.03-2028.03，主持

学术成果（代表性论文）

1.Jialian Zheng^#, Kuili Liang^#, Zi-Qing Li^#, Zunsheng Chen, Jianzhong Lu, He Zhang, Beibei Yi, Quanzhe Li, Qiuling Yang, Jinrong Li, Zhihan Zhang,* Guozhu Zhang,* and Rui Guo*, Copper-Catalyzed Regio- and Diastereoselective Dearomative Carbosilylation of Unactivated Arenes by Intercepting the Dienyl Radical. Angew. Chem. Int. Ed. 2026, 65, e202523719. (# contributed equally)

2.He Zhang^#, Wei Gu^#, Jialian Zheng, Jianzhong Lu, Quanzhe Li, Yuzhu Liu, Xiaotian Qi*, Guozhu Zhang*, Rui Guo*, Ligand Evolution-Enabled Enantioselective C(sp³)-H Azidation. J. Am. Chem. Soc. 2025, 147, 40010–40023. (# contributed equally)

3.Zhengze Wu^#, Kai Li^#, Mengxia Liao, Chunxiang Pan, Bin Yang, Xi Ma, Hengyu Huo, Binbin Tu, Guozhu Zhang*, Rui Guo*, Photoinduced Copper-Catalyzed Enantioselective Alkylalkynylation of Alkenes via Polarity-Matched Hydrogen Atom Transfer. J. Am. Chem. Soc. 2025, 147, 22072–22083. (# contributed equally)

4.Beibei Yi, He Zhang, Chunxiang Pan, Jianzhong Lu, Quanzhe Li, Kaiyao Yuan, Qian Xing, Wenxuan Chen, Xiaoya An, WMWW Kandegama*, Guozhu Zhang*, Rui Guo*, Hydroalkylation of Unactivated Alkenes with Amides via Photoredox Catalysis and Triple Hydrogen Atom Transfer. Angew. Chem. Int. Ed. 2025, 64 e202516794.

5.He Zhang^#, Wei Gu^#, Quanzhe Li, Jialian Zheng, Junying Xiao, Yuhan Kang, WMWW Kandegama, Xiaotian Qi*, Guozhu Zhang*, and Rui Guo*, Photoinduced Copper-Catalyzed α-C(sp³)-H Azidation of Amines via Aryl Radical-Mediated 1,5-Hydrogen Atom Transfer. ACS Catal. 2025, 15, 15425–15434. (# contributed equally)

6.Mengxia Liao^#, Cuihuan Geng^#, Zhengze Wu, Chunxiang Pan, Chenwei Wang, Guanghui Meng, Xiaoyan Zuo, Ying Zhu, Xiaotian Qi*, Guozhu Zhang*, Rui Guo*, Copper-Catalyzed Enantioselective Three-Component Fluoroalkylalkynylation of Unactivated Alkenes. ACS Catal. 2025, 15, 1693–1703. (# contributed equally)

7.J. Lu, K. Yuan, J. Zheng, H. Zhang, S. Chen, J. Ma, X. Liu, B. Tu, G. Zhang*, R, Guo*, Photoinduced Electron Donor Acceptor Complex-Enabled α-C(sp³)-H Alkenylation of Amines. Angew. Chem. Int. Ed. 2024, 63, e202409310.

8.J. Li^#, S. Li^#, G.-H. Cui, K. Yuan, C. Wang, C. Yang, G. Zhang^*, R. Guo^*, Photoinduced Copper-Catalyzed Regio- and Enantioselective Alkynylation of Epoxides. ACS Catal. 2024, 14, 7553–7561. (# contributed equally)

9.J. Zheng, H. Zhang, S. Kong, Y. Ma, Q. Du, B. Yi, G. Zhang^*, and R. Guo^*, Copper-Catalyzed General and Selective α-C(sp3)–H Silylation of Amides via 1,5-Hydrogen Atom Transfer. ACS Catal. 2024, 14, 1725–1732.

Before CCNU:

10.Rui Guo, Chao Shu^*, Guozhu Zhang^*, “Photoinduced Metal-free α-C–H Borylation of Aliphatic Amines”, Chem, 2022, 8, 2902-2904.

11.Rui Guo^‡, Haijing Xiao^‡, Sijia Li, Yixin Luo, Jiahui Bai, Mengzhen Zhang, Xiaotian Qi^*, Yinlong Guo^*, Guozhu Zhang^*, “Photoinduced Copper-Catalyzed Asymmetric C(sp³)-H Alkynylation of Cyclic Amines by Intramolecular 1,5-Hydrogen Atom Transfer”, Angew. Chem. Int. Ed., 2022, 61, e202208232. (‡: contributed equally)

12.Rui Guo^‡, Xiaotian Qi^‡, Hengye Xiang, Paul Geaneotes, Ruihan Wang, Peng Liu^*and Yi-Ming Wang^*, “Stereodivergent Alkyne Hydrofluorination Using Protic Tetrafluoroborates as Tunable Reagents” Angew. Chem. Int. Ed., 2020, 59, 16651−16660. (‡: contributed equally)

13.Rui Guo and Guozhu Zhang^*, “Expedient Synthesis of 1,5-Diketones by Rhodium-Catalyzed Hydroacylation Enabled by C−C Bond Cleavage” J. Am. Chem. Soc., 2017, 139, 12891−12894.

14.Rui Guo^‡, Xinxin Zheng^‡, Dayong Zhang^*, Guozhu Zhang^*, “Rhodium(I)-catalyzed stereoselective [4+2] cycloaddition of oxetanols with alkynes through C(sp³)–C(sp³) bond cleavage” Chem. Sci., 2017, 8, 3002−3006. (‡: contributed equally)

随时欢迎对有机化学感兴趣的同学联系～