个人信息
姓名：蔡萌
学历：博士
职称：副教授
E-mail：caimeng2016@ccnu.edu.cn
教育与研究经历
2022－至今 华中师范大学，化学学院，副教授
2019－2022 华中师范大学，化学学院，讲师
2016－2019 华中师范大学，化学学院，师资博士后
2014－2016 美国俄勒冈州立大学，基因组研究与生物计算中心，联培培养
2009－2016 中国农业大学，植物病理学，博士
2005－2009 中国农业大学，植物保护专业，学士
研究领域与兴趣
1. 活性小分子分子靶标的发现与功能研究
2. 杀菌剂的生物活性、作用机制及抗药性机制的研究
承担项目与课题信息
1. 国家自然科学基金面上项目，32372605，2024.01-2027.12，主持。
2. “十四五”国家重点专项项目，2022YFD1700200，项目骨干。
3. 湖北省自然科学基金面上项目，2023AFB880，2023.07-2025.06，主持。
4. 国家自然科学基金青年基金，31701820，2018.01-2020.12，主持。
5. 教育部重点实验室开放课题重点项目，2018HBSQGDKFA01，2019.01- 2020.12，主持。
6. 中国博士后科学基金面上资助，2017M622486， 2018.01-2019.12，主持。
7. 湖北省自然科学基金青年项目，2017CFB232，2017.01-2018.12，主持。
8. 高校基本科研业务费，CCNU16A05053，2016.10-2018.10，主持。
9. 国家自然科学基金面上基金，21877047，2019.01-2022.12，项目骨干。
10. 国家自然科学基金面上基金，21877046，2019.01-2022.12，项目骨干。
11. 国家自然科学基金青年基金，21807084，2019.01-2021.12，项目骨干。
学术成果（代表性论文）
【1】 Yuan Zhou, Yingying Qin, Huan Zhou, Tuotuo Zhang, Jiangtao Feng, Dan Xie, Lingling Feng, Hao Peng, Hongwu He*, Meng Cai*. Design, synthesis, high algicidal potency, and putative mode of action of new 2-cyclopropyl-4-aminopyrimidine hydrazones. Pesticide Biochemistry and Physiology, 2022: 105098.
【2】 Tengjiao Li＃, Meng Cai＃, Weizhen Wang, Tan Dai, Can Zhang, Borui Zhang, Jinghuan Shen, Yuke Wang, Xili Liu. PcCesA1 is involved in the polar growth, cellulose synthesis, and glycosidic linkage crosslinking in the cell wall of Phytophthora capsici. International Journal of Biological Macromolecules, 2022, 208: 720-730.
【3】 Bizhu Lv, Ruying Zhong, Yue Wang, Guang Li, Siyun Zhang, Lei Yang, Meng Cai*, Jin Zhang, Zhiyan Lu*, Haibing Li*, Xiao-Bing Zhang. Construction of Micropore Membranes for Efficient Separation of Chiral Pesticides Based on Layer-by-Layer Technology. ACS Agricultural Science & Technology, 2022, 2(6): 1230-1238.
【4】 Meng Cai＃, Tengjiao Li＃, Xiaohong Lu, Lei Chen, Qian Wang, Xili Liu. Multiple Mutations in the Predicted Transmembrane Domains of the Cellulose Synthase 3 (CesA3) of Phytophthora capsici can Confer Semi-dominant Resistance to Carboxylic Acid Amide Fungicides. International Journal of Biological Macromolecules, 2021: 2343-2351.
【5】 Yuan Zhou＃, Meng Cai＃, Huan Zhou, Leifeng Hou, Hao Peng, Hongwu He. Discovery of efficient inhibitors against pyruvate dehydrogenase complex component E1 with bactericidal activity using computer aided design. Pesticide Biochemistry and Physiology, 2021, 177: 104894.
【6】 Meng Cai＃, Can Zhang＃, Weizhen Wang, Qin Peng, Jiangqiang Miao, Brett M. Tyler, Xili Liu. Stepwise accumulation of mutations in CesA3 in Phytophthora sojae results in increasing resistance to CAA fungicides. Evolutionary Applications, 2021, 14(4):996-1008.
【7】 Yuan Zhou, Shasha Zhang, Meng Cai, Kaixing Wang, Jiangtao Feng, Dan Xie, Lingling Feng, Hao Peng, Hongwu He. Design, Synthesis, and Antifungal Activity of 2,6-Dimethyl-4-aminopyrimidine Hydrazones as PDHc-E1 Inhibitors with a Novel Binding Mode. Agric. Food Chem. 2021, 69, 21, 5804–5817.
【8】 Can Zhang, Meng Cai, Shanshan Chen, Fan Zhang, Tongshan Cui, Zhaolin Xue, Weizhen Wang, Borui Zhang, Xili Liu. The consensus Nglyco -X-S/T motif and a previously unknown Nglyco -N-linked glycosylation are necessary for growth and pathogenicity of Phytophthora. Environmental Microbiology, 2021, 23(9): 5147-5163.
【9】 Yuan Zhou, Shasha Zhang, Meng Cai, Kaixing Wang, Jiangtao Feng, Dan Xie, Lingling Feng, Hao Peng, Hongwu He. Design, Synthesis, and Antifungal Activity of 2,6-Dimethyl-4-aminopyrimidine Hydrazones as PDHc-E1 Inhibitors with a Novel Binding Mode. Journal of Agricultural and Food Chemistry, 2021, 69(21): 5804-5817.
【10】 Meng Cai＃, Jianqiang Miao＃, Fengping Chen, Botao Li, Xili Liu. Survival cost and diverse molecular mechanisms of Magnaporthe oryzae isolates resistance to epoxiconazole. Plant Disease, 2021, 105(2): 473 - 480.
【11】 Junbo He, Haifeng He, Meng Cai, Feng Zhao, Hongwu He. Insight into the halogen bonding between PA-1 ligand and pyruvate dehydrogenase complex E1 component by crystal structure, DFT calculation, and molecular docking. Journal of Molecular Structure, 2020, 1199:126991.
【12】 Yuan Zhou, Jiangtao Feng, Dan Xie, Hao Peng, Meng Cai*, Hongwu He*. Synthesis and activity of 1,2,3-triazole aminopyrimidines against cyanobacteria as PDHc-E1 competitive inhibitors. Journal of Agricultural and Food Chemistry, 2019, 67(45): 12538-12546.
【13】 Meng Cai＃, Zhiwen Wang＃, Xiaoxia Ni, Yanhua Hou, Qin Peng, Xiang Gao, Xili Liu. Insights from the proteome profile of Phytophthora capsici in response to the novel fungicide SYP-14288. PeerJ, 2019, 7: e7626.
【14】 Weizhen Wang, Zhaolin Xue, Jianqiang Miao, Meng Cai, Can Zhang, Tengjiao Li, Borui Zhang, Brett M. Tyler, Xili Liu. PcMuORP1, an oxathiapiprolin-resistance gene, functions as a novel selection marker for Phytophthora transformation and CRISPR/Cas9 mediated genome editing. Frontiers in Microbiology, 2019: 2402.
【15】 Jiangtao Feng, Haifeng He, Yuan Zhou, Xiaoliang Guo, Honglin Liu, Meng Cai, Fang Wang, Lingling Feng, Hongwu He. Design, synthesis and biological evaluation of novel inhibitors against cyanobacterial pyruvate dehydrogenase multienzyme complex E1. Bioorganic & Medicinal Chemistry, 2019 pii: S0968-0896(18)32059-5.
【16】 Yuan Zhou, Shasha Zhang, Hongwu He, Wen Jiang, Leifeng Hou, Dan Xie, Meng Cai, Hao Peng, Lingling Feng. Design and synthesis of highly selective pyruvate dehydrogenase complex E1 inhibitors as bactericides. Bioorganic & Medicinal Chemistry, 2018(26): 84-95.
【17】 Yuan Zhou, Jiangtao Feng, Hongwu He, Leifeng Hou, Wen Jiang, Dan Xie, Lingling Feng, Meng Cai, Hao Peng. Design, synthesis and potency of pyruvate dehydrogenase complex E1 inhibitors against cyanobacteria. Biochemistry, 2017(56): 6491-6502.
【18】 Meng Cai＃, Jianqiang Miao＃, Song Xi, Dong Lin, Yang Bi, Lei Chen, Brett M. Tyler, Xili Liu. C239S mutation in the β-tubulin of Phytophthora sojae confers resistance to zoxamide. Frontiers in Microbiology, 2016, 7: 762.
【19】 Jianqiang Miao＃, Meng Cai＃, Xue Dong, Li Liu, Dong Lin, Can Zhang, Zhili Pang, Xili Liu. Resistance assessment for oxathiapiprolin in Phytophthora capsici and the detection of a point mutation (G769W) in PcORP1 that confers resistance. Frontiers in Microbiology, 2016, 7: 615.
【20】 Meng Cai＃, Dong Lin＃, Lei Chen, Yang Bi, Lu Xiao, Xi-li Liu. M233I mutation in the β-Tubulin of Botrytis cinerea confers resistance to zoxamide. Scientific Reports, 2015, 5: 16881.
