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Associate Professor

    ZHANG Dan

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    2012.01-now: Central China Normal University, School of Chemistry. Lecturer.

    2010.10-2011.10: University of Illinois at Urbana-Champaign, America. Department of Chemistry (Advisor, Prof.Yi Lu). Joint PhD Program supported by China Scholarship Council (CSC).

    2006.09-2011.12: Wuhan University, Ph. D. Candidate of Chemistry, College of Chemistry & MolecularSciences. (Advisor, Prof. Xiang Zhou)

    2000.09-2004.07: Sichuan University, Bachelor of Engineering, College of Chemical Engineering, Major inPharmaceutical Engineering

    Research Fields and Interests

    Small molecule – DNAinteractions

    Nucleic acid – protein interactions

    Cancer cell targeting, imagingand therapy

    Selected Publications

    1.Zhao,D., Dong, X. W., Jiang, N.,Zhang, D.,*Liu, C. L.* Highly Selective Recognition of Parallel and Anti- parallel Thrombin-Binding AptamerG-quadruplexes by Different Fluorescent Dyes.Nucleic Acids Res.2014.42, 11612-11621.

    2.Jiang, N., Yang, C. L., Dong, X. W., Sun,X. L.,Zhang, D.,*Liu, C. L.* An ESIPT Fluorescent Probe Sensitive to Proteina-helixStructures. Org. Biomol. Chem.,2014.Org. & Biomol. Chem.2014.12, 5250–5259.

    3. Huang, X. Y., Dong,X. W., Li, X., Meng, X. G.,Zhang, D.,*Liu, C. L.*Metal-polybenzimidazole complexes as a nonviral gene carrier: Effects of the DNA affinity on gene delivery.J. Inorg. Biochem.2013,129,102-111.

    4. Zheng, K. W.,Zhang,D., Zhang, L. X., Hao, Y. H., Zhou, X., Tan, Z.* Dissecting the Strand Folding Orientation and Formation of G-Quadruplexes in Single- and Double-Stranded Nucleic Acids by Ligand-Induced PhotocleavageFootprinting.J. Am. Chem. Soc.2011,133, 1475-1483.

    5. Xu, L1.,Zhang, D1., ( joint first authors) Huang, J., Deng, M. G., Zhang, M., Zhou, X.* High FluoresenceSelectivity and Visual Detection of G-quadruplex Structures by A Novel Dinuclear Ruthenium Complex.Chem. Commun.2010,46,743-745.

    6. Du, Y. H1.,Zhang, D1.,( joint first authors)Chen, W., Zhang, M., Zhou, Y. Y., Zhou,X.* Cationic N-confused Porphyrin Derivative as a New Molecule Scaffold for G-quadruplex Recognition.Bioorg. Med. Chem.2010,18,1111-1116.

    7. Ma, H1.,Zhang, M1.,Zhang, D1.,( joint first authors)Huang, R., Zhao, Y., Yang, H., Liu, Y. J.,Weng, X. C., Zhou, Y. Y., Deng, M. G., Xu, L., Zhou, X.* Corrole Isomers:Conformation Induction, Stabilization of Telomere G-quadruplex and Highly Bindings to Promoter G-quadruplexes.Chem.Asian. J.2010,5, 114.

    8.Zhang, D1.,( joint first authors)Deng, M. G1., Xu, L., Zhou, Y.Y., Yuwen, J., Zhou, X.* The Sensitive and Selective Optical Detection of Mercury (II) Ions by Using a Phosphorothioate DNAzyme Strategy.Chem. Eur. J.2009,15, 8117-8120.

    9. Fu, B. Q1.,Zhang, D1.,( joint firstauthors)Weng, X. C.,Zhang, M., Ma, H., Ma, Y. Z., Zhou, X.* Cationic Metal-Corrole Complexes:Design, Synthesis, and Properties of Guanine-Quadruplex Stabilizers.Chem.Eur. J.2008,14, 9431-9441.

    10. Deng, M. G.,Zhang,D., Zhou, Y. Y., Zhou, X.* Highly Effective Colorimetric and Visual Detection of Nucleic Acids Using an Asymmetrically Split Peroxidase DNAzyme.J.Am. Chem. Soc.2008,130, 13095-13102.

    Honors and Awards

    1. Dan Zhang has been awarded a Metallomics Poster Prizeat the 6thAsian Biological Inorganic Chemistry Conference (AsBIC-VI). Hong Kong Polytechnic University, HongKong, China. 5th-8thNovember 2012.

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