姓 名： 朱晓磊
学 历： 博士
职 称： 教授
电 话： 15327348018
E—mail： xlzhu@mail.ccnu.edu.cn
个人主页：http://chemyang.ccnu.edu.cn/
学习简历：
2003年9月–2008年12月 华中师范大学 硕博连读（有机化学）
1999年9月–2003年6月 安庆师范学院 学士学位（化学教育）
工作简历：
2019年-现在，教授，华中师范大学化学学院
2010-2019年, 副教授，华中师范大学化学学院
2008-2010, 讲师，华中师范大学化学学院
1.氟唑菌酰羟胺增产的分子机制与新型杀菌剂的设计合成研究，国家自然科学基金面上项目，2025.01-2028.12，主持人，22477040， 直接经费50万
2.原创性靶标成靶性评价和靶向小分子探针设计, 2022YFD1700204, 所属项目：新机制农药分子靶标的发现及应用， 国家重点研发计划， 2022 年11 月 至 2026 年12 月， 364万，直接经费196万。
3.人工智能等新兴技术辅助的绿色农药分子设计，2023YFD1700500, 国家重点研发计划， 2023 年12 月 至 2027 年12 月，参与，40万
4.作物提质增产剂的创制，企业委托项目，2021年11月-2026年11月，1500万
5.湖北省科技攻关项目，安全生物农药和生物制品技术攻关（HBNYHXGG2023-3）项目下任务四：重要作物有害生物绿色防控产品研发及其关键技术创制，2023.01-2025.12，参与，35万。
6.靶向琥珀酸脱氢酶的绿色高效杀菌剂创制及应用，湖北省重点研发计划项目，2020.01-2022.12，主持人，2020BBA052，200万
7.琥珀酸脱氢酶与酰胺类抑制剂的相互作用研究及反抗性杀菌剂分子设计，国家自然科学基金面上项目，2020.01-2023.12，主持人，21977035， 66万
1.Ying Dong, Jun-Chao Zhang, Jia-Yue Sun, Ze-Wei Guan, Guang-Kai Yao, Xiao-Lei Zhu, Design and synthesis of triazole sulfonamide inhibitors of bc1 complex. Adv. Agrochem, 2025, https://doi.org/10.1016/j.aac.2025.01.003
2.Ma JH, Ying MX, Lu ZW, Guan ZW, Zhang CQ, Zhu XL, Yang GF. The resistance mechanism of B_P225F and B_H272R mutations in succinate dehydrogenase in Botrytis cinerea. Int J Biol Macromol. 2025，293，139360-139369.
3.Wang YX, Ye Y, Li ZW, Cui GR, Shi XX, Dong Y, Jiang JJ, Sun JY, Guan ZW, Zhang N, Wu QY, Wang F, Zhu XL, Yang GF. Cryo-EM Structures Reveal the Unique Binding Modes of Metyltetraprole in Yeast and Porcine Cytochrome bc1 Complex Enabling Rational Design of Inhibitors. J Am Chem Soc. 2024 146, 33903-33913.
4.Dong Y, Guan XY, Guan ZW, Zhang JC, Zhu XL, Yang GF. Triazole Sulfonamide Derivates: Inhibitors of the bc1 Complex to Control Cucumber Downy Mildew. J Agric Food Chem. 2024, 72 , 27513-27520.
5.Zeng LQ, Chen Q, Wei G, Chen W, Zhu XL, Yang GF. Comprehensive Overview of the Amide Linker Modification in the Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2024, 72, 26027-26039.
6.Zhou LM, Yang JF, Li HH, Chen W, Li YW, Zhu XL, Yang GF. Discovery of Novel Oxathiapiprolin Derivatives as Potent Fungicide Candidates. J Agric Food Chem. 2024，72，17649-17657.
7.Dong Y.; Li B.; Yin MX.; Liu Z.; Niu Y.; Wu QY.; Zhu XL.; Yang GF. The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc1 Complex and Its Structural Modification. J. Agric. Food Chem. 2024, 72, 3755-3762.
8.Huang YH, Wei G, Wang WJ, Liu Z, Yin MX, Guo WM, Zhu XL, Yang GF. Structure-Based Discovery of New Succinate Dehydrogenase Inhibitors via Scaffold Hopping Strategy. J. Agric. Food Chem. 2023, 71, 18292-18300.
9.Li, J. L.; Yang, J. F.; Zhou, L. M.; Cai, M.; Huang, Z. Q.; Liu, X. L.; Zhu, X. L.; Yang, G. F. Design and Synthesis of Novel Oxathiapiprolin Derivatives as Oxysterol Binding Protein Inhibitors and Their Application in Phytopathogenic Oomycetes. J. Agric. Food Chem. 2023, 71, 9519−9527.
10.Li, H.; Liu, Z.; Dong, Y.; Wang, Y. X.; Zhu, X. L. Design, Synthesis, and Fungicidal Evaluation of Novel N‑Methoxy Pyrazole-4-Carboxamides as Potent Succinate Dehydrogenase Inhibitors. J. Agric. Food Chem. 2023, 71, 2610−2615.
11.Ye, Y.; Guan, Z. W.; Zhu, X. L.; Yang, G. F. Chitin synthase: A potential agricultural and therapeutic target. Adv. Agrochem, 2022, 1, 87–88.
12.Chen T.; Zhang, R..; Wang, Y. X.; Gao, M. Q.; Chen, Q.; Zhu, X. L.; Yang, G. F. Discovery of Novel Cytochrome bc1 Complex Inhibitor Based on Natural Product Neopeltolide. Lett. Drug. Des. Discov. 2022, 19, 263-268.
13.Huang YH, Wei G, Liu Z, Lu Q, Jiang JJ, Zhu XL, Yang GF. Discovery of N-Methoxy-(biphenyl-ethyl)-pyrazole-carboxamides as Novel Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2022,70, 14480-14487
14.Li, H.; Wang, YX.; Zhu, X.L.; Yang, G. F. Discovery of a Fungicide Candidate Targeting Succinate Dehydrogenase via Computational Substitution Optimization. J. Agric. Food Chem. 2021, 69, 13227–13234.
15.We,i G.; Huang, M. W.; Wang, W. J.; Wu, Y.; Mei, S. F.; Zhou, L. M.; Mei, L. C.; Zhu, X. L.*; Yang, G. F. * Expanding the Chemical Space of Succinate Dehydrogenase Inhibitors via the Carbon–Silicon Switch Strategy. J. Agric. Food Chem. 2021, 69, 13, 3965–3971.
16.Chen, T.; Li, W. Q.; Liu, Z.; Jiang, W.; Liu, T.; Yang, Q.; Zhu, X. L. Discovery of Biphenyl−Sulfonamides as Novel β‑N‑Acetyl‑D‑Hexosaminidase Inhibitors via Structure-Based Virtual Screening. J. Agric. Food Chem. 2021, 69, 12039-12047.
17.Li, H.; Gao, MQ.; Chen, Y.; Wang, YX.; Zhu, X.L.; * Yang, G. F. Discovery of Pyrazine-Carboxamide-Diphenyl-Ethers as Novel Succinate Dehydrogenase Inhibitors via Fragment Recombination. J. Agric. Food Chem. 2020, 68, 14001-14008.
18.Li, J. L.; Zhou, L. M.; Gao, M. Q.; Huang, Z. Q.; Liu, X. L.; Zhu, X. L. * Yang, G. F. Design, synthesis, and fungicidal evaluation of novel oxysterol binding protein inhibitors for combatting resistance associated with oxathiapiprolin. Pestic. Biochem. Physiol, 2020, 169, 104673-104681.
19.Xiong, M. Q.; Chen, T.; Wang, Y. X.; Zhu, X. L.; * Yang, G. F. Design and synthesis of potent inhibitors of bc1 complex based on natural product neopeltolide. Bioorg. Med. Chem. Lett., 2020, 30, 127324-127328.
20.李华，武圆，高梦琪，朱晓磊，杨光富，含二苯醚结构单元的新型烟酰胺类衍生物的合成及杀菌活性研究，现代农药，2020，19，1-8.
