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个人信息

   名:杨文超 

   历:博士 

   称:教授

   话:027-67867706

Emailtomyang@mail.ccnu.edu.cn

教育与研究经历

男,198010月出生。湖北枣阳人。

19999月至20036月:华中师范大学化学学院学习,获理学学士学位;

20039月至200910月:华中师范大学化学学院有机化学专业研究生学习,获理学博士学位;

20059月至200910月:作为联合培养博士生在美国肯塔基大学药学院学习和研究;

200912月~201012月:美国肯塔基大学药学院博士后研究。

200912月至20126月:华中师范大学化学学院,讲师

200912月至20176月:华中师范大学化学学院,副教授

20177月至:华中师范大学化学学院,教授

 

研究领域与兴趣

1. 农药化学生物学;

2. 生物分析化学;

3. 基于靶标结构的新型药物分子的合理设计。

承担项目与课题信息

1. 国家自然科学青年基金(21102052):以细胞色素bc1复合物为靶标的新型杀菌剂的合理设计,2012.01~2014.12,主持人。

2. 国家科技支撑计划课题(2011BAE06B05):化学、生物与信息技术相结合的农药创制技术研究,2011.01~2015.12,研究骨干。

3. 国家自然科学基金面上项目,21372094、靶向细胞色素bc1复合物Qi位点的新型杀

菌剂的设计与合成、2014/01-2017/1280万元、主持人。

4. 国家自然科学基金面上项目,21672079HPPD的催化反应机理及其与抑制剂相互作用的研究、2017/01-2020/1265万元、主持人。

5. 国家重点研发计划,2017YFA0505203、蛋白质机器的外源小分子标记与动态调控、2017/07-2022/06164万元、子课题负责人。

6. 湖北省杰出青年基金项目,2018CFA072、靶向人弹性蛋白酶的探针及其在肺癌诊断与治疗中的应用、2018/01-2020/1210万元、主持人。

7. 广东省科技计划项目20140107高效丁酰胆碱酯酶突变体的制备及其在农药残留检测中的应用2016/01-2017/1230万元、主持人。

8. 湖北省技术创新重大项目,2016ABA099、新型超高效除草剂喹草酮的创新及应用研究2017/01-2019/12100万元、研究骨干

学术兼职

中国化学会会员

香港学者协会会员

美国药学会会员

学术成果

 

1) Liu, S.Y.; Xiong, H.; Yang, J.Q.; Yang, S.H.; Li, Y, Yang, W.C. *; Yang, G.F.* Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging. ACS Sens. 2018. doi: 10.1021/acssensors.8b00697. 入选美国化学会ACS Editors' Choice.

2) Xiong, H.; Li, R.R; Liu, S.Y.; Wu, F.X.; Yang, W.C. *; Yang, G.F.* Discovery of Specific Nonpeptide Probe for Chymotrypsin via Molecular Docking-Based Virtual Screening and the Application. ACS Appl. Bio Mater. 2018, 1, 310−317.

3) Wu, S.; He, Y.J.; Qiua, X.X.; Yang, W.C.; Liu, W.C.; Li, X.H.; Li, Y.; Sheng, H.M.; Wang, R.X.; Yue, Z.Y.; Zhao, Y.X.*. Targeting the potent Beclin 1–UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking. Proc. Natl. Acad. Sci. U.S.A. 2018. 115. E5669-E5678.

4) Xiong, H.; Yang, J.Q.; Kang, W.M.; Wu, F.X.; Zuo, J.L.; Zhou, Z.Y.; Yang, W.C. *; Yang, G.F.* Fluorogenic and chromogenic detection of carboxypeptidase Y with anonpeptide-based small-molecule probe. Sensors and Actuators B. 2018. 269. 127-134.

5) Yang, S.H.; Sun, Q.; Xiong, H.; Liu, S.Y.; Moosavi, B.; Yang, W.C. *; Yang, G.F.* Chem. Commun. 2017. 53, 3952-3955.

6) Ndikuryayo, F.; Moosavi, B.; Yang, W. C.;* Yang, G. F.* 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors: From Chemical Biology to Agrochemicals. J. Agric. Food Chem., 2017, 65, 8523–8537.

7) 熊浩,杨文超, * 杨光富. * 胆碱酯酶荧光探针的研究进展. 中国科学:化学201747933-944.

8) Wu, L.; Yang, S.H.; Xiong, H.; Yang, J.Q.; Guo, J.; Yang, W.C. *; Yang, G.F. Nonpeptide-Based Small-Molecule Probe for Fluorogenic and Chromogenic Detection of Chymotrypsin. Anal. Chem. 2017, 89, 3687-3693.

9) Wang, D.W.; Lin, H.Y.; He, B.; Wu, F.X.; Chen T.; Chen, Q.; Yang, W.C.*; Yang, G.F.* An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. J. Agric. Food Chem. 2016, 64, 8986-8993.

10) Xiong, L.; Zhu, X.L. *; Gao, H.W.; Fu, Y.; Hu S.Q.; Jiang, L.N.; Yang, W.C.; Yang, G.F.* Discovery of Potent Succinate-Ubiquinone Oxidoreductase Inhibitors via Pharmacophore-linked Fragment Virtual Screening Approach. J. Agric. Food Chem. 2016, 64, 4830-4837.

11) Sun Q.; Yang S.H; Wu L.; Dong Q.J.; Yang, W. C.*; Yang, G. F.* Detection of intracellular selenol-containing molecules using a fluorescent probe with near-Zero background signal. Anal. Chem. 2016, 88, 6084-6091.

12) Sun Q.; Yang S.H; Wu L.; Yang, W. C.*; Yang, G. F.* A Highly Sensitive and Selective Fluorescent Probe for Thiophenol Designed via a Twist-Blockage Strategy. Anal. Chem. 2016, 88, 2266-2272.

13) Xu, Y.L.; Lin, H.Y.; Ruan, X.; Yang, S.G.; Hao, G.F.; Yang, W.C.*; Yang, G.F.* Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors. Eur. J. Med. Chem. 2015, 92, 427-438.

14) Wang, D.W.; Lin, H.Y.; Cao, R.J.; Ming, Z.Z.; Chen T.; Hao, G.F.; Yang, W.C.*; Yang, G.F.* Design, synthesis and herbicidal activity of novel quinazoline-2,4-diones as 4-hydroxyphenylpyruvate dioxygenase inhibitors. Pest. Manag. Sci. 2015, 8, 1122-1132.

15) Wang, D.W.; Lin, H.Y.; Cao, R.J.; Yang, S.G.; Chen, Q.; Hao, G.F.; Yang, W.C. *; Yang, G.F.* Synthesis and Herbicidal Evaluation of Triketone-Containing Quinazoline-2,4-diones. J. Agric. Food Chem. 2014, 62, 11786-11796.

16) Xu, Y.L.; Lin, H.Y.; Cao, R.J.; Ming, Z.Z.; Yang, W.C.*; Yang, G.F.* Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Bioorg. Med. Chem. 2014, 22, 5194-5211.

17) Sun, Q.; Peng, D.Y.; Yang, S.G.; Zhu, X.L.; Yang, W.C.*; Yang, G.F.* Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase. Bioorg. Med. Chem. 2014, 22, 4784-91.

18) Li, J.; Zhang, C. F.; Yang, S. H.; Yang, W. C.*; Yang, G. F.* A coumarin-based fluorescent probe for selective and sensitive detection of thiophenols and its application. Anal. Chem. 2014, 86, 3037-3042.

19) Sun Q.; Li J.; Liu W. N.; Dong Q. J.; Yang, W. C.*; Yang, G. F.* Non-peptide-based fluorogenic small-molecule probe for elastase. Anal. Chem. 2013, 85, 11304-11311.

20) Li, J.; Zhang, C. F.; Ming, Z. Z.; Yang, W. C.*; Yang, G. F.* Novel coumarin-based sensitive and selective fluorescent probes for biothiols in aqueous solution and in living cells. RSC Adv., 2013, 3, 26059-26065.

21) Li, J.; Zhang, C. F.; Ming, Z. Z.; Hao, G. F.; Yang, W. C.*; Yang, G. F.* Coumarin-based novel fluorescent zinc ion probe in aqueous solution. Tetrahedron 2013, 69, 4743-4748.

22) Peng, D. Y.; Sun, Q.; Zhu, X.L.; Lin, H.Y.; Chen, Q.; Yang, W. C.*; Yang, G. F.* Design, Synthesis, and Bioevaluation of Benzamides: Novel Acetylcholinesterase Inhibitors with Multi-functions on Butylcholinesterase, Aβ Aggregation, and β-Secretase. Bioorg. Med. Chem. 2012, 20, 6739-6750.

23) Yang, W. C.; Li, H.; Wang, F.; Zhu, X.L.; Yang, G. F. * Rieske Iron–Sulfur Protein of the Cytochrome bc1 Complex: A Potential Target for Fungicide Discovery. Chembiochem 2012, 134, 1542-1551.

24) Yang, W. C.; Li J.; Li J.; Chen Q.; Yang G. F.* Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity. Bioorg. Med. Chem. Lett. 2012, 22, 1455-1458.

25) Yang, W. C.; AbdulHameed M. D.; Hamza A.; Zhan C.G.* New inhibitor of 3-phosphoinositide dependent protein kinase-1 identified from virtual screening. Bioorg. Med. Chem. Lett. 2012, 15, 1629-1632.

 

获奖及荣誉信息

1. 化学学院教学竞赛二等奖,2012

2. 第四届农药科学与环境安全暨第五届泛太平洋农药科学国际会议,优秀墙报奖,2012

3. 香江学者奖, 2013

4. 指导的研究生孙琦等获得湖北省大学生挑战杯三等奖,2013,

5. 指导的本科生周佳伟获得湖北省优秀本科毕业论文,2015

6. 指导的本科生王梓获得湖北省优秀本科毕业论文,2016

7. 指导的本科生余雷获得湖北省优秀本科毕业论文,2017

8. 指导的本科生左佳丽、周姿羽获得湖北省第十届大学生化学(化工)学术创新成果三等奖,2017

9. 指导的本科生郭吴英正获得湖北省第十一届大学生化学(化工)学术创新成果三等奖,2018

10. 指导的硕士研究生熊浩获得国家奖学金,2018